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回肠标准可消化组氨酸/赖氨酸对断奶仔猪（7-11kg）生长性能、肠道健康和含组氨酸蛋白动员的影响
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查看次数：2870
时间：2023-02-17
试验目的在于评估高于NRC需要量的回肠标准可消化组氨酸/赖氨酸（SID H/L）对断奶仔猪（7-11kg）生长性能、肠道健康和含组氨酸蛋白（包括血红蛋白、肌肽和胰蛋白酶原）动员的影响。
试验选用40 头断奶仔猪（26日龄；初重7.1 ± 0.5 kg），根据性别和初始体重的完全随机区组设计，分配至5种日粮处理。日粮中SID H/L分别为 26%、32%、38%、43% 和 49%，并饲喂14 天，日粮SID Lys含量为1.22%。在第0、7和 14 天分别记录采食量和体重。第 12 天采集血样。第14天对猪实施安乐死，采集胰腺、背最长肌、空肠中段和空肠粘膜样品。使用SAS的Proc Mixed对数据进行统计分析。
日粮处理对仔猪生长性能没有显著影响，但是SID H/L显著影响血红蛋白水平（P<0.05，36%时浓度最高，为12 g/dL）、空肠粘膜中免疫球蛋白A水平（IgA，P<0.05，35%时浓度最低，为1.25 μg/mg），空肠中绒毛高度（P=0.065，40%时最大，为536 μm）、胰腺中胰蛋白酶原含量（P=0.083，41%时含量最高，为242 pg/mg）和肌肉中肌肽水平（P=0.051，38%时浓度最高，为4.7 ng/mg）。日粮SID H/L线性提高肌肉中的蛋白质羰基（P<0.05，从1.95到2.80 nmol/mg），并减少肠细胞增殖（P<0.05，从29.1%到26.9%）。
总之，回肠标准可消化组氨酸/赖氨酸在35%-41%之间可以改善仔猪（7-11kg）肠道健康，并使含组氨酸蛋白水平达到峰值，这表明含组氨酸的蛋白质是确定组氨酸需要量时的有效标准。
The effects of standardized ileal digestible His to Lys ratio on growth performance, intestinal health, and mobilization of histidine-containing proteins in pigs at 7 to 11 kg body weight
The objectives were to evaluate the effects of standardized ileal digestible (SID) His:Lys ratio above the current NRC requirement on growth performance, intestinal health, and mobilization of His-containing proteins, including hemoglobin, carnosine, and trypsinogen, in nursery pigs from 7 to 11 kg body weight (BW). Forty pigs (26 d of age; initial BW of 7.1?±?0.5 kg) were allotted to 5 dietary treatments based on a randomized complete block design with sex and initial BW as blocks. Dietary treatments were supplemented with varying SID His to Lys ratios of 26%, 32%, 38%, 43%, and 49% and fed to pigs for 14 d (SID Lys?=?1.22%). Feed intake and BW were recorded at d 0, 7, and 14 to measure growth performance. Blood samples were collected on d 12. Pigs were euthanized on d 14 to collect pancreas, longissimus dorsi muscles, mid-jejunum, and jejunal mucosa. Data were analyzed using the Proc Mixed of SAS. Growth performance was not affected, whereas varying SID His to Lys ratio affected hemoglobin (P?<?0.05, max: 12 g/dL at 36%), immunoglobulin A (IgA, P?<?0.05, min: 1.25 μg/mg at 35%) in jejunal mucosa, villus height (P?=?0.065, max: 536 μm at 40%) in jejunum, trypsinogen (P?=?0.083, max: 242 pg/mg at 41%) in pancreas, and carnosine (P?=?0.051, max: 4.7 ng/mg at 38%) in muscles. Varying SID His to Lys ratios linearly increased (P?<?0.05, from 1.95 to 2.80 nmol/mg) protein carbonyl in muscles and decreased (P?<?0.05, from 29.1% to 26.9%) enterocyte proliferation. In conclusion, SID His to Lys ratio between 35% and 41% in diets fed to nursery pigs at 7 to 11 kg enhanced intestinal health and maximized concentrations of His-containing proteins, indicating that His-containing proteins are effective response criteria when determining His requirement.
文章来源：猪营养国际论坛
【免责声明】：文章来源于网络，我们对文中陈述观点判断保持中立，并不对文章观点负责。仅供读者参考。版权属于原作者。
试验选用40 头断奶仔猪（26日龄；初重7.1 ± 0.5 kg），根据性别和初始体重的完全随机区组设计，分配至5种日粮处理。日粮中SID H/L分别为 26%、32%、38%、43% 和 49%，并饲喂14 天，日粮SID Lys含量为1.22%。在第0、7和 14 天分别记录采食量和体重。第 12 天采集血样。第14天对猪实施安乐死，采集胰腺、背最长肌、空肠中段和空肠粘膜样品。使用SAS的Proc Mixed对数据进行统计分析。
日粮处理对仔猪生长性能没有显著影响，但是SID H/L显著影响血红蛋白水平（P<0.05，36%时浓度最高，为12 g/dL）、空肠粘膜中免疫球蛋白A水平（IgA，P<0.05，35%时浓度最低，为1.25 μg/mg），空肠中绒毛高度（P=0.065，40%时最大，为536 μm）、胰腺中胰蛋白酶原含量（P=0.083，41%时含量最高，为242 pg/mg）和肌肉中肌肽水平（P=0.051，38%时浓度最高，为4.7 ng/mg）。日粮SID H/L线性提高肌肉中的蛋白质羰基（P<0.05，从1.95到2.80 nmol/mg），并减少肠细胞增殖（P<0.05，从29.1%到26.9%）。
总之，回肠标准可消化组氨酸/赖氨酸在35%-41%之间可以改善仔猪（7-11kg）肠道健康，并使含组氨酸蛋白水平达到峰值，这表明含组氨酸的蛋白质是确定组氨酸需要量时的有效标准。
The effects of standardized ileal digestible His to Lys ratio on growth performance, intestinal health, and mobilization of histidine-containing proteins in pigs at 7 to 11 kg body weight
The objectives were to evaluate the effects of standardized ileal digestible (SID) His:Lys ratio above the current NRC requirement on growth performance, intestinal health, and mobilization of His-containing proteins, including hemoglobin, carnosine, and trypsinogen, in nursery pigs from 7 to 11 kg body weight (BW). Forty pigs (26 d of age; initial BW of 7.1?±?0.5 kg) were allotted to 5 dietary treatments based on a randomized complete block design with sex and initial BW as blocks. Dietary treatments were supplemented with varying SID His to Lys ratios of 26%, 32%, 38%, 43%, and 49% and fed to pigs for 14 d (SID Lys?=?1.22%). Feed intake and BW were recorded at d 0, 7, and 14 to measure growth performance. Blood samples were collected on d 12. Pigs were euthanized on d 14 to collect pancreas, longissimus dorsi muscles, mid-jejunum, and jejunal mucosa. Data were analyzed using the Proc Mixed of SAS. Growth performance was not affected, whereas varying SID His to Lys ratio affected hemoglobin (P?<?0.05, max: 12 g/dL at 36%), immunoglobulin A (IgA, P?<?0.05, min: 1.25 μg/mg at 35%) in jejunal mucosa, villus height (P?=?0.065, max: 536 μm at 40%) in jejunum, trypsinogen (P?=?0.083, max: 242 pg/mg at 41%) in pancreas, and carnosine (P?=?0.051, max: 4.7 ng/mg at 38%) in muscles. Varying SID His to Lys ratios linearly increased (P?<?0.05, from 1.95 to 2.80 nmol/mg) protein carbonyl in muscles and decreased (P?<?0.05, from 29.1% to 26.9%) enterocyte proliferation. In conclusion, SID His to Lys ratio between 35% and 41% in diets fed to nursery pigs at 7 to 11 kg enhanced intestinal health and maximized concentrations of His-containing proteins, indicating that His-containing proteins are effective response criteria when determining His requirement.
文章来源：猪营养国际论坛
【免责声明】：文章来源于网络，我们对文中陈述观点判断保持中立，并不对文章观点负责。仅供读者参考。版权属于原作者。
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